Nature Reviews Microbiology contents March 2015 Volume 13 Number 3 pp 1-184

Advertisement asm2015 May 30 — June 2, 2015 | New Orleans, Louisiana American Society for Microbiology Today's leading scientists and tomorrow's innovators will present their latest research across microbiology's broad range of specialties at asm2015. Don't miss the opportunity to attend asm2015 for less! Register on or before April 12 to attend at a discounted rate.www.asm.org/asm2015 TABLE OF CONTENTS March 2015 Volume 13 Number 3 Impact Factor23.317 * In this issue Research Highlights News and Analysis Correspondence Reviews Also this month  Featured article: New technologies: methods and applications  Featured article: Vector-borne diseases  Featured article: Rising to the challenge: accelerated pace of discovery transforms marine virology Jennifer R. Brum & Matthew B. Sullivan Subscribe Facebook RSS Recommend to library Twitter Advertisement Don't let your data go to waste... Scientific Data helps researchers make the most of their data, offering publication in a peer reviewed open access journal. We welcome data of all sizes, from all areas of science. What's unique? A new type of article providing detailed descriptions of scientifically valuable datasets, maximising data discoverability and reuse. Discover what we can do for your data  RESEARCH HIGHLIGHTS Synthetic biology: GMOs in lockdown p125 | doi:10.1038/nrmicro3443 Two studies describe the design of safer genetically modified organisms that cannot grow in natural ecosystems because they require synthetic amino acids for growth. PDF Antimicrobials: A new drug for resistant bugs p126 | doi:10.1038/nrmicro3429 A study reports the discovery of a new antibiotic with a novel mechanism of action and a low propensity to select for resistance. PDF Parasite biology: PINning downTheileria  p126 | doi:10.1038/nrmicro3444 A new study identifies the mechanistic basis for host cell transformation by Theileria spp. parasites. PDF Bacterial genetics: sRNA toolkit for Vibrio  p128 | doi:10.1038/nrmicro3434 Bassler and colleagues show that a small regulatory RNA from Vibrio harveyi regulates multiple target mRNAs by distinct mechanisms, which influences quorum sensing dynamics. PDF Parasite biology: An anchor forPlasmodium invasion p128 | doi:10.1038/nrmicro3436 This study identifies CyRPA as the anchor of an essential Plasmodium falciparum invasion complex at the merozoite surface. PDF Bacterial physiology: Putting the 'BREX' on phage replication p129 | doi:10.1038/nrmicro3437 This study identifies bacteriophage exclusion (BREX) as a novel bacterial defence system that protects against lytic and lysogenic phage infection. PDF IN BRIEF Fungal physiology: A phospho-switch for pathogenesis | Bacterial pathogenesis:Crossing the barriers | Symbiosis: Metabolites in differentiation | Microbiome:Secret behind commensal resilience revealed | Bacterial physiology: Riboswitch control is key to ZTP mystery | Microbiome: A dysbiotic enteric viromePDF Microbiology JOBS of the week Postdoctoral Fellow in Molecular Microbiology Imaging Ecole Polytechnique Fédérale de Lausanne (EPFL)  PhD Student Position in Microbiology Belgian Nuclear Research Centre Professor- Researcher: Microbiology Institut national de la recherche scientifique (INRS) More Science jobs from Microbiology EVENT EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology 11.10.15 Heidelberg, Germany More science events from NEWS AND ANALYSIS GENOME WATCH R-M systems go on the offensive John Lees & Rebecca A. Gladstonep131 | doi:10.1038/nrmicro3435 This month's Genome Watch explores how genetic variation in restriction-modification systems fromStreptococcus pneumoniae contributes to the defence against phages and to bacterial virulence. PDF CORRESPONDENCE The importance of soil archives for microbial ecology Jan Dolfing & Youzhi Fengp1 | doi:10.1038/nrmicro3382-c1 Full Text | PDF REVIEWS Marine microbial community dynamics and their ecological interpretation Jed A. Fuhrman, Jacob A. Cram & David M. Needhamp133 | doi:10.1038/nrmicro3417In this Review, Fuhrman and colleagues summarize our current understanding of marine microbial community dynamics at various scales — from hours to decades — and consider how long-term time series illustrate important ecological concepts such as community resilience and seasonality, as well as interactions among microorganisms in the global oceans. Abstract | Full Text | PDF Article series: New technologies: methods and applications Rising to the challenge: accelerated pace of discovery transforms marine virology Jennifer R. Brum & Matthew B. Sullivanp147 | doi:10.1038/nrmicro3404Marine viruses have important roles in modulating the dynamics of microbial life in the global oceans. Brum and Sullivan discuss the recent technological advances that are facilitating an accelerated pace of discovery in marine virology, including metagenomics and several cultivation-dependent and cultivation-independent tools. Abstract | Full Text | PDF Article series: Vector-borne diseases Post-translational protein modifications in malaria parasites Christian Doerig, Julian C. Rayner, Artur Scherf & Andrew B. Tobinp160 | doi:10.1038/nrmicro3402Plasmodium falciparum, the malaria parasite, relies on post-translational modifications of proteins to regulate several fundamental aspects of its life cycle and pathogenesis. Here, Doerig and colleagues focus on the roles of protein phosphorylation, acetylation, methylation and lipidation in P. falciparum biology, and they discuss how the enzymes that mediate these modifications can be targeted by novel antimalarial drugs. Abstract | Full Text | PDF | Supplementary information Pathogen manipulation of B cells: the best defence is a good offence Katharina Nothelfer, Philippe J. Sansonetti & Armelle Phaliponp173 | doi:10.1038/nrmicro3415B cells are essential components of the immune response against infection. However, several bacteria, viruses and parasites are able to infect B cells and manipulate B cell functions and survival. Here, the authors review how pathogens use B cells as reservoirs, manipulate B cell differentiation and interfere with B cell survival, and they discuss the implications for ongoing immune responses. 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