Nature Reviews Neurology - Table of Contents alert Volume 11 Issue 3

TABLE OF CONTENTS
March 2015 Volume 11 Number 3
Impact Factor14.103 *	In this issue Research Highlights News and Views Reviews Perspectives Correspondence Also this month  Featured article: Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders Panos Stathopoulos, Harry Alexopoulos & Marinos C. Dalakas
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RESEARCH HIGHLIGHTS Parkinson disease: Treatment needs vary between Parkinson disease subtypes Published online: 24 February 2015 p123 | doi:10.1038/nrneurol.2015.19 PDF Infectious disease:Neurological disease in children linked to enterovirus D68 Published online: 17 February 2015 p124 | doi:10.1038/nrneurol.2015.18 PDF Neurodegenerative disease:RBM3, a protein upregulated during hibernation, provides new insights into neurodegeneration Published online: 03 February 2015 p124 | doi:10.1038/nrneurol.2015.9 PDF Dementia: Anticholinergic medications might increase the risk of AD Published online: 10 February 2015 p125 | doi:10.1038/nrneurol.2015.11 PDF Multiple sclerosis:Neuroimaging provides insights into cognitive dysfunction in MS Published online: 10 February 2015 p126 | doi:10.1038/nrneurol.2015.15 PDF IN BRIEF Parkinson disease: Perception of treatment cost influences response to placebo in patients with Parkinson disease | Motor neuron disease: TUDCA shows early promise for the treatment of amyotrophic lateral sclerosis| Epilepsy: A potential neurotoxic interaction between an antidepressant and an antiepileptic drug | Infectious disease: Dietary restriction has beneficial effects in experimental cerebral malaria | Parkinson disease: Dietary cholesterol and monounsaturated fats are linked to reduced risk of Parkinson disease | Dementia:Subjective memory impairment points to future risk of dementia | Stroke: B lymphocytes are implicated in poststroke dementia | Neuro-oncology: Altered resting state network connectivity in the brains of patients with gliomaPDF Neurology JOBS of the week Oklahoma Neurology Opportunity Physician Specialty Partners More Science jobs from Neurology EVENT 22nd World Congress of Neurology 31st Oct 2015 Santiago, Chille More science events from
NEWS AND VIEWS
Dementia: Type 2 diabetes has a slow and insidious effect on cognition Hiroyuki UmegakiPublished online: 17 February 2015 p127 | doi:10.1038/nrneurol.2015.17Type 2 diabetes mellitus (T2DM) has been linked with cognitive impairment and dementia. A new cross-sectional study reports that T2DM is also associated with dementia in Parkinson disease, and another study describes the long-term clinical course of diabetes-associated cognitive dysfunction; however, the mechanisms through which T2DM affects the brain are not completely understood. Full Text | PDF
Traumatic brain injury: Age at injury influences dementia risk after TBI Victoria E. Johnson & William StewartPublished online: 23 December 2014 p128 | doi:10.1038/nrneurol.2014.241Traumatic brain injury (TBI) is increasingly recognized as a risk factor for dementia. New data provide further support for this association and demonstrate the influence of age at injury and injury severity on dementia risk after TBI, revealing that even mild TBI increases dementia risk in those aged [ge]65 years. Full Text | PDF
Epilepsy: Long-term rates of childhood-onset epilepsy remission confirmed Matti Sillanpää & Dieter SchmidtPublished online: 27 January 2015 p130 | doi:10.1038/nrneurol.2014.262Approximately 60% of people diagnosed with childhood-onset epilepsy are known to be in 5-year remission and off medication, or in complete remission. A new report confirms and consolidates these findings and gives further evidence of the long-term stability of remission in epilepsy. A future risk of relapse is suggested, which might be an overestimate. Full Text | PDF
Stroke: Risk assessment to prevent recurrence after mild stroke or TIA Amy Y. X. Yu & Shelagh B. CouttsPublished online: 17 February 2015 p131 | doi:10.1038/nrneurol.2015.16Stroke has a heavy socioeconomic burden. A subset of patients with transient or nondisabling cerebral ischaemic events will experience recurrent stroke, leading to permanent deficits. Two new studies tackle the challenge of identifying the patients most at risk for recurrent stroke via examination of radiological and serum biomarkers. Full Text | PDF
REVIEWS
Multiple sclerosis—a quiet revolution Richard M. Ransohoff, David A. Hafler & Claudia F. LucchinettiPublished online: 17 February 2015 p134 | doi:10.1038/nrneurol.2015.14The past 20 years have seen remarkable progress in research into multiple sclerosis (MS), resulting in a veritable armamentarium of treatment options. Ransohoff and colleagues reflect on three major eras of drug development to date. The authors also offer guidance on how best to select between various therapeutics, and look to the future of MS research. Abstract | Full Text | PDF
Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders Panos Stathopoulos, Harry Alexopoulos & Marinos C. DalakasPublished online: 27 January 2015 p143 | doi:10.1038/nrneurol.2014.260Mounting evidence suggests that autoantibodies contribute to the pathogenesis of demyelination in the PNS and CNS, and that such autoantibodies might impair saltatory conduction mediated by the node of Ranvier. In this Review, the authors provide a detailed description of the molecular anatomy of the node of Ranvier, discuss nodal, paranodal and juxtaparanodal proteins as likely autoantigens, and examine the role of autoantibodies in the pathogenesis of demyelinating disease. Abstract | Full Text | PDF
White matter hyperintensities, cognitive impairment and dementia: an update Niels D. Prins & Philip ScheltensPublished online: 17 February 2015 p157 | doi:10.1038/nrneurol.2015.10White matter hyperintensities (WMHs) are frequently seen on brain MRI in older people, and are thought to result from chronic ischaemia associated with cerebral small vessel disease. Prins and Scheltens provide a timely Review on WMHs, including their relationship with cognitive decline and dementia. The authors also discuss how WMHs might provide a therapeutic target to prevent the onset and progression of dementia. Abstract | Full Text | PDF
Age-related hearing impairment—a risk factor and frailty marker for dementia and AD Francesco Panza, Vincenzo Solfrizzi & Giancarlo LogroscinoPublished online: 17 February 2015 p166 | doi:10.1038/nrneurol.2015.12Age related hearing impairment (ARHI, also known as presbycusis) is an important frailty marker, and could be a reversible risk factor for dementia and Alzheimer disease. Poor verbal communication and depletion of cognitive reserve might causally link ARHI to cognitive decline and frailty; hearing aids and cognitive training might, thus, provide a strategy to delay or prevent cognitive deterioration. In this Review, Panza and colleagues discuss the interplay between cognitive impairment, ARHI and frailty in older age. Abstract | Full Text | PDF
PERSPECTIVES
OPINION Can we measure long-term treatment effects in multiple sclerosis? Maria Pia Sormani & Paolo BruzziPublished online: 23 December 2014 p176 | doi:10.1038/nrneurol.2014.237The short-term safety and efficacy of IFN-β in patients with multiple sclerosis are well established, but less is known about this drug when taken over years and decades. Sormani and Bruzzi discuss the difficulties associated with designing studies of the long-term treatment effects of IFN-β. They then present techniques that have been employed to minimize potential sources of bias. The authors conclude that long-term use of IFN-β reduces clinical progression, but important questions relating to mortality warrant further investigation. Abstract | Full Text | PDF
CORRESPONDENCE
Abuse liability—study the intended patient populations Alec B. O'Connor, Dennis C. Turk & Robert H. DworkinPublished online: 10 February 2015 p182 | doi:10.1038/nrneurol.2014.16-c1 Full Text | PDF
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