Nature Communications - 18 February 2015

WEEKLY CONTENT ALERT 18 February 2015  Featured image: Erb et al. demonstrate that indole is a volatile signal that primes plant tissues to respond to insect damage. Latest content: Articles Corrigendum Errata Advertisement Nature Communications is now fully open access All new submissions toNature Communications, if accepted, will be published open access and an article processing charge will apply. For more information visit thewebsite. Many research funders and institutions make funds available to pay open access APCs: please consult our open access funding page to check if your funder or institution has funding available. For advice on whether you are eligible for APC funding and help in approaching funders and institutions please contact us atopenaccess@nature.com. Journal homepage Recommend to library Web feed   Advertisement Animation: Depression and its treatment In this animation from Nature Neuroscience, we explore the circuits affected in depression, and illustrate the molecular and cellular changes thought to underlie the effects of chronic stress and its remediation by antidepressant drugs. Access the Animation free online.  Produced with support from: Janssen      LATEST ARTICLES View all Articles     Mutation within the hinge region of the transcription factorNr2f2 attenuates salt-sensitive hypertension Sivarajan Kumarasamy, Harshal Waghulde, Kathirvel Gopalakrishnan, Blair Mell, Eric Morgan and Bina Joe Transcription factor Nr2f2 is linked to high blood pressure in humans and animals. Using hypertensive rats that have been genetically modified to express a mutant Nr2f2 that binds stronger to transcription factor Fog2, the authors show that the interaction between these two proteins is critical for blood pressure regulation. 17 February 2015 | doi: 10.1038/ncomms7252 Medical research  Strong interactive growth behaviours in solution-phase synthesis of three-dimensional metal oxide nanostructures Jung Min Lee, You-Shin No, Sungwoong Kim, Hong-Gyu Park and Won Il Park It has been suggested that the growth rate of nanocrystals is affected by the size and density of surrounding crystals. Here, the authors study the anisotropic growth of zinc oxide nanorod arrays, and show that rod diameter and height are interdependent, and may be affected by local interactions. 17 February 2015 | doi: 10.1038/ncomms7325 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Trends and oscillations in the Indian summer monsoon rainfall over the last two millennia Ashish Sinha, Gayatri Kathayat, Hai Cheng, Sebastian F. M. Breitenbach, Max Berkelhammer, Manfred Mudelsee, Jayant Biswas and R. L. Edwards Summertime rainfall over South Asia has declined in the last few decades, possibly due to human aerosols. Here, the authors present a record of Indian monsoon rainfall over the last two millennial and suggest that large natural variability may mask any forced changes in monsoon. 17 February 2015 | doi: 10.1038/ncomms7309 Earth Sciences  Climate science  The polymeric mucin Muc5ac is required for allergic airway hyperreactivity Christopher M. Evans, Dorota S. Raclawska, Fani Ttofali, Deborah R. Liptzin, Ashley A. Fletcher, Daniel N. Harper, Maggie A. McGing, Melissa M. McElwee, Olatunji W. Williams, Elizabeth Sanchez, Michelle G. Roy, Kristen N. Kindrachuk, Thomas A. Wynn, Holger K. Eltzschig, Michael R. Blackburn, Michael J. Tuvim, William J. Janssen, David A. Schwartz and Burton F. Dickey Asthma is associated with mucus overproduction; however, the immunological consequences of excess mucus remain poorly understood. Here the authors show that formation of airway plugs by mucus promotes airway hypersensitivity, while deletion of mucous component Muc5acablates it independently of inflammation. 17 February 2015 | doi: 10.1038/ncomms7281 Biological Sciences  Immunology  Action of the Hsp70 chaperone system observed with single proteins João M. Nunes, Manajit Mayer-Hartl, F Ulrich Hartl and Daniel J. Müller The bacterial Hsp70 chaperone system consists of DnaJ, DnaK and GrpE. To understand how these chaperones cooperate, Nunes et al. monitor refolding immunoglobulin domains using single-molecule force microscopy to demonstrate that the ‘holdase’ DnaJ can show foldase activity and suggest that GrpE can facilitate substrate release from DnaK. 17 February 2015 | doi: 10.1038/ncomms7307 Biological Sciences  Biochemistry  Biophysics  Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi, Robert J. Fletterick, Mark J. S. Kelly and Danica Galonić Fujimori Histone lysine methylation plays crucial roles in controlling gene expression. Here the authors demonstrate that the activity of the histone lysine demethylase KDM5A is regulated through a feedback mechanism involving communication between the histone tail-binding and catalytic domains. 17 February 2015 | doi: 10.1038/ncomms7204 Biological Sciences  Biochemistry  Biophysics Molecular biology  Visualization of molecular fluorescence point spread functions via remote excitation switching fluorescence microscopy OPEN Liang Su, Gang Lu, Bart Kenens, Susana Rocha, Eduard Fron, Haifeng Yuan, Chang Chen, Pol Van Dorpe, Maarten B. J. Roeffaers, Hideaki Mizuno, Johan Hofkens, James A. Hutchison and Hiroshi Uji-i Plasmonic nanoparticles can dramatically enhance the optical properties of molecules but background scattering is a limiting factor. Su et al. use remote excitation by plasmons on nanowires to better access single fluorophore point spread functions for improved sensing and super-resolution imaging. 17 February 2015 | doi: 10.1038/ncomms7287 Physical Sciences  Applied physics  Nanotechnology Optical physics  Misfit accommodation mechanism at the heterointerface between diamond and cubic boron nitride OPEN Chunlin Chen, Zhongchang Wang, Takeharu Kato, Naoya Shibata, Takashi Taniguchi and Yuichi Ikuhara Interfaces between two materials often show interesting properties. Here, the authors demonstrate that diamond and cubic boron nitride, the hardest materials known, can be grown on top of each other through a novel misfit accommodation mechanism, forming a two-dimensional electron gas at the interface. 17 February 2015 | doi: 10.1038/ncomms7327 Physical Sciences  Condensed matter  Materials science  Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity OPEN Takuhiro Matsumura, Yo Sugawara, Masahiro Yutani, Sho Amatsu, Hideo Yagita, Tomoko Kohda, Shin-Ichi Fukuoka, Yutaka Nakamura, Shinji Fukuda, Koji Hase, Hiroshi Ohno and Yukako Fujinaga It is unclear how ingested botulinum neurotoxin invades the host to cause illness. Here, the authors show that the toxin complex containing neurotoxin, hemagglutinin (HA), and NTNHA proteins traverses the epithelial barrier via HA-glycoprotein 2 interaction and endocytosis by Peyer’s patch microfold cells. 17 February 2015 | doi: 10.1038/ncomms7255 Biological Sciences  Medical research  Emergence of coherence in the charge-density wave state of 2H-NbSe2 OPEN U. Chatterjee, J. Zhao, M. Iavarone, R. Di Capua, J. P. Castellan, G. Karapetrov, C. D. Malliakas, M. G. Kanatzidis, H. Claus, J. P. C. Ruff, F. Weber, J. van Wezel, J. C. Campuzano, R. Osborn, M. Randeria, N. Trivedi, M. R. Norman and S. Rosenkranz Charge density waves are described by a complex order parameter whose amplitude is expected to vanish at the transition temperature. This study shows that the transition in 2H-NbSe2 is driven by fluctuations of the phase of the order parameter, with a finite amplitude surviving in the disordered state. 17 February 2015 | doi: 10.1038/ncomms7313 Physical Sciences  Condensed matter  Trans-mitochondrial coordination of cristae at regulated membrane junctions OPEN Martin Picard, Meagan J. McManus, György Csordás, Péter Várnai, Gerald W. Dorn II, Dewight Williams, György Hajnóczky and Douglas C. Wallace Mammalian mitochondria are capable of inter-organelle communication, but connections between mitochondria have not been defined. Here, Picard et al. report the presence of inter-mitochondrial junctions, electron-dense regions with coordinated inner membrane cristae that do not depend on mitofusins for their formation. 17 February 2015 | doi: 10.1038/ncomms7259 Biological Sciences  Cell biology  Dynamics of an initially spherical bubble rising in quiescent liquid Manoj Kumar Tripathi, Kirti Chandra Sahu and Rama Govindarajan The motion of gas bubbles in liquid is highly relevant to heat and mass transfer in our daily lives. Here, Tripathi et al.simulate a bubble rising under gravity in three-dimensions and find sharp boundaries in parameter space between different types of dynamics, and the coupled evolution of shape. 17 February 2015 | doi: 10.1038/ncomms7268 Physical Sciences  Applied physics  Fluids and plasma physics  Primitive macrophages control HSPC mobilization and definitive haematopoiesis Jana Travnickova, Vanessa Tran Chau, Emmanuelle Julien, Julio Mateos-Langerak, Catherine Gonzalez, Etienne Lelièvre, Georges Lutfalla, Manuela Tavian and Karima Kissa Haematopoietic stem/progenitor cells (HSPCs) transform from aortic endothelium into migratory cells that move through stroma and enter circulation to colonize haematopoietic tissues. Here the authors show that HSPCs' passage is facilitated by primitive macrophages that secrete extracellular matrix-degrading enzymes. 17 February 2015 | doi: 10.1038/ncomms7227 Biological Sciences  Developmental biology  Unveiling pseudospin and angular momentum in photonic graphene Daohong Song, Vassilis Paltoglou, Sheng Liu, Yi Zhu, Daniel Gallardo, Liqin Tang, Jingjun Xu, Mark Ablowitz, Nikolaos K. Efremidis and Zhigang Chen Artificial photonic graphene, a honeycomb array of evanescently coupled waveguides, has proven to be a useful tool for investigating graphene physics in various optical settings. Here, Song et al. demonstrate pseudospin-mediated vortex generation and topological charge flipping in otherwise uniform optical beams. 17 February 2015 | doi: 10.1038/ncomms7272 Physical Sciences  Condensed matter  Materials science  Optical physics  Bandgap tunability at single-layer molybdenum disulphide grain boundaries Yu Li Huang, Yifeng Chen, Wenjing Zhang, Su Ying Quek, Chang-Hsiao Chen, Lain-Jong Li, Wei-Ting Hsu, Wen-Hao Chang, Yu Jie Zheng, Wei Chen and Andrew T. S. Wee Molybdenum disulphide is a two-dimensional material that, unlike graphene, has a nonzero bandgap. Here, the authors demonstrate that the bandgap of single-layer molybdenum disulphide grown on graphite by chemical vapour deposition changes with distance from the grain boundary 17 February 2015 | doi: 10.1038/ncomms7298 Physical Sciences  Materials science  Macroscopic rotation of photon polarization induced by a single spin OPEN Christophe Arnold, Justin Demory, Vivien Loo, Aristide Lemaître, Isabelle Sagnes, Mikhaïl Glazov, Olivier Krebs, Paul Voisin, Pascale Senellart and Loïc Lanco The recently observed rotation of a photon's polarization by interaction with a single solid state spin has potential implications in quantum computing. Here, Arnold et al. demonstrate enhanced spin–photon coupling and polarization rotation via a coupled quantum dot/micropillar cavity system. 17 February 2015 | doi: 10.1038/ncomms7236 Physical Sciences  Applied physics  Optical physics  Insight into spin transport in oxide heterostructures from interface-resolved magnetic mapping F. Y. Bruno, M. N. Grisolia, C. Visani, S. Valencia, M. Varela, R. Abrudan, J. Tornos, A. Rivera-Calzada, A. A. Ünal, S. J. Pennycook, Z. Sefrioui, C. Leon, J. E. Villegas, J. Santamaria, A. Barthélémy and M. Bibes Induced magnetic ordering at complex oxide interfaces holds potential for spintronic applications. Here, Bruno et al.image the imprinting of domains between ferromagnetic and antiferromagnetic thin films in oxide heterostructures, and demonstrate the effects on tunnelling magnetotransport. 17 February 2015 | doi: 10.1038/ncomms7306 Physical Sciences  Condensed matter  Materials science  Transparent air filter for high-efficiency PM2.5capture Chong Liu, Po-Chun Hsu, Hyun-Wook Lee, Meng Ye, Guangyuan Zheng, Nian Liu, Weiyang Li and Yi Cui Particulate matter pollution is a public health concern in industrialized and urban areas. Here, the authors control the surface chemistry and microstructure of filtration materials to fabricate effective and transparent air filters for the capture of PM2.5 pollutants. 16 February 2015 | doi: 10.1038/ncomms7205 Chemical Sciences  Materials science  One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization OPEN Kyohei Ozaki, Katsuaki Kawasumi, Mari Shibata, Hideto Ito and Kenichiro Itami Bottom-up synthesis of nanographenes is highly desirable. Here, the authors report one-shot annulative π-extension reactions that occur at the convex armchair edge of polycyclic aromatic hydrocarbons, and show that unfunctionalized precursors can be used for π-component assembly and extension. 16 February 2015 | doi: 10.1038/ncomms7251 Chemical Sciences  Materials science  Organic chemistry  Indole is an essential herbivore-induced volatile priming signal in maize OPEN Matthias Erb, Nathalie Veyrat, Christelle A. M. Robert, Hao Xu, Monika Frey, Jurriaan Ton and Ted C. J. Turlings Herbivore attack of plant tissue primes non-attacked tissue to respond more strongly to subsequent attacks. Here, Erbet al. identify indole as an airborne priming signal that enhances herbivore-induced defensive-volatile and stress-hormone production in systemic tissues and neighbouring plants. 16 February 2015 | doi: 10.1038/ncomms7273 Biological Sciences  Ecology  Plant sciences  Mechanical work makes important contributions to surface chemistry at steps OPEN M. F. Francis and W. A. Curtin Surface strain affects the performance of catalysts. Here, the authors present computational evidence that mechanical strain of late transition metals can modify binding energies at stepped surfaces through a mechanical energy contribution yielding chemical trends unique from the established d-band model. 13 February 2015 | doi: 10.1038/ncomms7261 Chemical Sciences  Catalysis  Materials science Physical chemistry  Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling OPEN Joseph Robertson, Guillaume Jacquemet, Adam Byron, Matthew C. Jones, Stacey Warwood, Julian N. Selley, David Knight, Jonathan D. Humphries and Martin J. Humphries Protein phosphorylation is known to play an important role in cell adhesion signalling. Robertson et al. present a proteomic resource mapping the phosphorylation states of proteins isolated from adhesion complexes and, taking advantage of this data set, show that the cell cycle kinase CDK1 may influence cell adhesion. 13 February 2015 | doi: 10.1038/ncomms7265 Biological Sciences  Cell biology  Systems biology  Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG OPEN Nicolas Fischer, Greg Elson, Giovanni Magistrelli, Elie Dheilly, Nicolas Fouque, Amélie Laurendon, Franck Gueneau, Ulla Ravn, Jean-François Depoisier, Valery Moine, Sylvain Raimondi, Pauline Malinge, Laura Di Grazia, François Rousseau, Yves Poitevin, Sébastien Calloud, Pierre-Alexis Cayatte, Mathias Alcoz, Guillemette Pontini, Séverine Fagète et al. Bispecific antibodies allow for novel therapeutic approaches but industrial-scale production and immunogenicity represent significant challenges. Here Fischer et al. describe a unique human bispecific antibody format that exploits differing light chains to overcome these obstacles. 12 February 2015 | doi: 10.1038/ncomms7113 Biological Sciences  Biotechnology  Immunology  Selective Sirt2 inhibition by ligand-induced rearrangement of the active site OPEN Tobias Rumpf, Matthias Schiedel, Berin Karaman, Claudia Roessler, Brian J. North, Attila Lehotzky, Judit Oláh, Kathrin I. Ladwein, Karin Schmidtkunz, Markus Gajer, Martin Pannek, Clemens Steegborn, David A. Sinclair, Stefan Gerhardt, Judit Ovádi, Mike Schutkowski, Wolfgang Sippl, Oliver Einsle and Manfred Jung The involvement of the sirtuin family of lysine deacylases in disease, metabolism and ageing makes them promising pharmaceutical targets. Rumpfet al. present structures of human Sirt2 in complex with two highly selective drug-like inhibitors, and show that they act by rearranging the enzyme’s active site. 12 February 2015 | doi: 10.1038/ncomms7263 Biological Sciences  Biochemistry  Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells OPEN Hong-Bo Wang, Hua Zhang, Jing-Ping Zhang, Yan Li, Bo Zhao, Guo-Kai Feng, Yong Du, Dan Xiong, Qian Zhong, Wan-Li Liu, Huamao Du, Man-Zhi Li, Wen-Lin Huang, Sai Wah Tsao, Lindsey Hutt-Fletcher, Yi-Xin Zeng, Elliott Kieff and Mu-Sheng Zeng Epstein–Barr virus (EBV) is involved in the development of some cancers including nasopharyngeal carcinoma. Here, the authors show that a direct interaction between the viral protein gB and a host protein, neuropilin 1, is required for EBV infection of nasopharyngeal epithelial cells. 11 February 2015 | doi: 10.1038/ncomms7240 Biological Sciences  Cell biology  Virology  Imaging single cells in a beam of live cyanobacteria with an X-ray laser Gijs van der Schot, Martin Svenda, Filipe R. N. C. Maia, Max Hantke, Daniel P. DePonte, M. Marvin Seibert, Andrew Aquila, Joachim Schulz, Richard Kirian, Mengning Liang, Francesco Stellato, Bianca Iwan, Jakob Andreasson, Nicusor Timneanu, Daniel Westphal, F. Nunes Almeida, Dusko Odic, Dirk Hasse, Gunilla H. Carlsson, Daniel S. D. Larsson et al. Imaging live cells at nanometre resolution is challenging because radiation damage kills the cells during exposure. Here, the authors overcome this difficulty in a ‘diffraction before destruction’ experiment using an X-ray laser and record signal to 4 nm resolution on a free-flying cell. 11 February 2015 | doi: 10.1038/ncomms6704 Physical Sciences  Applied physics  Optical physics  Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway OPEN Mengtan Xing, Mingrui Yang, Wei Huo, Feng Feng, Leizhen Wei, Wenxia Jiang, Shaokai Ning, Zhenxin Yan, Wen Li, Qingsong Wang, Mei Hou, Chunxia Dong, Rong Guo, Ge Gao, Jianguo Ji, Shan Zha, Li Lan, Huanhuan Liang and Dongyi Xu DNA double-strand breaks (DSBs), a highly deleterious form of DNA damage, are associated with multiple types of broken ends. Here, the authors identify a XRCC4-like factor that functions in the non-homologous end-joining DNA repair pathway to repair DSBs with complex broken ends. 11 February 2015 | doi: 10.1038/ncomms7233 Biological Sciences  Cell biology  Molecular biology  Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition OPEN Aaron Goldman, Biswanath Majumder, Andrew Dhawan, Sudharshan Ravi, David Goldman, Mohammad Kohandel, Pradip K. Majumder and Shiladitya Sengupta Adaptive resistance is an emerging cause of chemotherapy failure in cancer. Here the authors show that adaptive resistance to taxanes is mediated by the upregulation of SFK/Hck survival signalling, and that sequential administration of taxanes and SFK/Hck inhibition restores tumor cell chemosensitivity. 11 February 2015 | doi: 10.1038/ncomms7139 Biological Sciences  Cancer  Control of cytoplasmic dynein force production and processivity by its C-terminal domain OPEN Matthew P. Nicholas, Peter Höök, Sibylle Brenner, Caitlin L. Wynne, Richard B. Vallee and Arne Gennerich Cytoplasmic dynein from the yeast S. cerevisiae behaves distinctly from mammalian dyneins, despite structural conservation. Here, Nicholas et al. identify a C-terminal domain in mammalian dynein that restricts force generation and travel distance, which, when removed, allows mammalian dynein to behave like its yeast counterpart. 11 February 2015 | doi: 10.1038/ncomms7206 Biological Sciences  Biophysics  Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues OPEN Adi Tzur-Balter, Zohar Shatsberg, Margarita Beckerman, Ester Segal and Natalie Artzi The degradation of materials used in biological applications has an important bearing on their long term performance. Here, the authors show how porous silicon nanoparticle degradation can be acceleratedin vivo through the influence of local tissue pathology, likely influencing drug delivery performance. 11 February 2015 | doi: 10.1038/ncomms7208 Biological Sciences  Cancer  Materials science Nanotechnology  Undesired usage and the robust self-assembly of heterogeneous structures Arvind Murugan, James Zou and Michael P. Brenner Biological and synthetic systems seek to assemble complex structures, such as protein or DNA assemblies, out of many distinct building blocks. Here, the authors show that the optimal supply of building blocks must account for the composition of undesired structures and not just the desired structure. 11 February 2015 | doi: 10.1038/ncomms7203 Chemical Sciences  Biophysics  Physical chemistry  Evolution of gene network activity by tuning the strength of negative-feedback regulation Weilin Peng, Ping Liu, Yuan Xue and Murat Acar Cells rewire their gene networks to adapt to the environment, yet little is known about the mechanisms underlying gene network evolution. Here, the authors show that changing promoters in the galactose network between two species of yeast changes network inducibility levels and affects fitness. 11 February 2015 | doi: 10.1038/ncomms7226 Biological Sciences  Evolution  Genetics  Identity of aPlasmodium lactate/H+symporter structurally unrelated to human transporters Binghua Wu, Janis Rambow, Sinja Bock, Julia Holm-Bertelsen, Marie Wiechert, Alexandra Blancke Soares, Tobias Spielmann and Eric Beitz Malaria parasites generate metabolic energy through anaerobic glycolysis, yielding lactate and protons that are then secreted out of the parasite cell by an unknown transporter. Here, the authors identify and characterize a lactate/proton transporter that may be carrying out such function in Plasmodium. 11 February 2015 | doi: 10.1038/ncomms7284 Biological Sciences  Biochemistry  Microbiology    Nature Communications JOBS of the week Postdoctoral Fellow Karolinska Institutet (KI) Research Assistant Queen Mary University of London Postdoctoral Research Scientist The Babraham Institute Research Associate The Sainsbury Laboratory (TSL) Postdoctoral Fellow | Chromatin Biology UT Southwestern Medical Center at Dallas Bioinformatics Scientist II Children's Hospital of Philadelphia PhD Position Available University of Miami Ph.D. position University of Antwerp - Belgium Junior Group Leaders Université de Lyon 2 Junior Research Group Leader Positions Center for Chronic Immunodeficiency at the University Medical Center Freiburg More Science jobs from Nature Communications EVENT Evolution 2015 26.06.15 Guarujá, Brazil More science events from       LATEST CORRIGENDUM     Corrigendum: Experimental evidence of replica symmetry breaking in random lasers N. Ghofraniha, I. Viola, F. Di Maria, G. Barbarella, G. Gigli, L. Leuzzi and C. Conti 12 February 2015 | doi: 10.1038/ncomms7300 Physical Sciences  Optical physics        LATEST ERRATA     Erratum: Conserved and host-specific features of influenza virion architecture Edward C. Hutchinson, Philip D. Charles, Svenja S. Hester, Benjamin Thomas, David Trudgian, Mónica Martínez-Alonso and Ervin Fodor 17 February 2015 | doi: 10.1038/ncomms7446 Biological Sciences  Biochemistry  Microbiology  Virology      Erratum: Interplay between Kondo effect and Ruderman–Kittel–Kasuya–Yosida interaction Henning Prüser, Piet E. Dargel, Mohammed Bouhassoune, Rainer G. Ulbrich, Thomas Pruschke, Samir Lounis and Martin Wenderoth 13 February 2015 | doi: 10.1038/ncomms7237 Physical Sciences  Condensed matter  Materials science      Erratum: Evidence for an oxygen evolving iron–oxo–cerium intermediate in iron-catalysed water oxidation Zoel Codolà, Laura Gómez, Scott T. Kleespies, Lawrence Que, Miquel Costas and Julio Lloret-Fillol 12 February 2015 | doi: 10.1038/ncomms7405 Chemical Sciences  Catalysis  Inorganic chemistry      Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans Federico Pelisch, Remi Sonneville, Ehsan Pourkarimi, Ana Agostinho, J. Julian Blow, Anton Gartner and Ronald T. Hay 12 February 2015 | doi: 10.1038/ncomms7352 Biological Sciences  Cell biology      Advertisement Nature Reviews Clinical Oncology Focus on Paediatric cancer  Paediatric oncology is a bustling field with a wide remit, from genomic studies to surgical innovations. This Focus issue aims to look at a number of the key issues, and the cutting-edge research, surrounding treating arguably our most vulnerable patients. Produced with support of a grant from Bristol-Myers Squibb   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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