Nature Reviews Endocrinology - Table of Contents alert Volume 11 Issue 3

TABLE OF CONTENTS
March 2015 Volume 11 Number 3
Impact Factor12.958 *	In this issue Research Highlights News and Views Correction Reviews Perspectives Also this month  Featured article: Long non-coding RNAs as regulators of the endocrine system Marko Knoll, Harvey F. Lodish & Lei Sun
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RESEARCH HIGHLIGHTS Top Obesity: The many faces of leptin—a novel role for leptin signalling in obesity-induced hypertension Published online: 23 December 2014 p129 | doi:10.1038/nrendo.2014.231 PDF Infection: Resistance to infection—skin adipocytes in the spotlight Published online: 20 January 2015 p130 | doi:10.1038/nrendo.2015.1 PDF Diabetes: Hepatic lipogenesis independent of insulin in type 2 diabetes mellitus—a paradox clarified Published online: 20 January 2015 p130 | doi:10.1038/nrendo.2015.5 PDF Immunology: ILC2s regulate obesity and drive beiging of white adipose tissue Published online: 23 December 2014 p131 | doi:10.1038/nrendo.2014.233 PDF Genetics: New mutations in Cushing disease identified Published online: 23 December 2014 p131 | doi:10.1038/nrendo.2014.235 PDF Obesity: Gut-specific FXR agonism Published online: 27 January 2015 p131 | doi:10.1038/nrendo.2015.4 PDF Stem cells: Back to the origins—identifying the skeletal stem cell Published online: 03 February 2015 p132 | doi:10.1038/nrendo.2015.14 PDF IN BRIEF Neuroendocrine cancer:Blocking β-catenin signalling—a future therapy for pancreatic neuroendocrine tumours? | Therapy: GLP-1—estrogen conjugate superior to GLP-1 alone in decreasing food intake and protecting pancreatic β cells | Metabolism: PPARγ agonists and adipocyte browning—new insights | Diabetes: Increasing the number of intestinal L cells—an alternative to GLP-1 therapy in type 2 diabetes mellitus?PDF Endocrinology JOBS of the week Biomedical Science: Associate Professor in Endocrinology University of Reading Assistant / Associate Professor Tenure Track University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism More Science jobs from Endocrinology EVENT European Congress for Endocrinology (ECE 2015) 16.05.15 Dublin, Ireland More science events from
NEWS AND VIEWS
Genetics: The genomic landscape of papillary thyroid carcinoma Massimo Santoro & Rosa M. MelilloPublished online: 25 November 2014 p133 | doi:10.1038/nrendo.2014.209A landmark article by The Cancer Genome Atlas Research network describes the genetic landscape of papillary thyroid carcinoma (PTC). This study identifies oncogenic driver lesions, highlights molecular pathways that drive cancer formation and defines clinically relevant disease subtypes. These findings have far-reaching implications with respect to molecular diagnosis and targeted therapies for PTC. Full Text | PDF
Bone: Fracture risk in the JUPITER trial—statin treatment or not? Peter VestergaardPublished online: 23 December 2014 p135 | doi:10.1038/nrendo.2014.232Observational studies suggest that statin treatment has a fracture-preventive effect; however, there is only limited supporting evidence from randomized controlled trials. Now, results from the JUPITER trial show that rosuvastatin treatment does not reduce the risk of fractures and, further, that levels of high sensitivity C-reactive protein are not associated with fracture risk. Full Text | PDF
Diabetes: Elevated risk of mortality in type 1 diabetes mellitus Janet K. Snell-Bergeon & David M. MaahsPublished online: 13 January 2015 p136 | doi:10.1038/nrendo.2014.245Type 1 diabetes mellitus (T1DM) is associated with increased risk of mortality, despite improvements in management of glucose levels and treatment of cardiovascular risk factors. A population-based study of individuals with T1DM and control individuals matched for age and sex has used glycaemic control to characterize the excess risk of overall and cardiovascular mortality. Full Text | PDF
Bone: Will breast cancer chemoprevention stand on 'solid bone'? Larry J. Suva & Issam MakhoulPublished online: 16 December 2014 p138 | doi:10.1038/nrendo.2014.220Aromatase inhibitors are the most effective agents for preventing breast cancer; however, their use is associated with bone loss and an increased risk of fractures. Sestak and colleagues show that administration of an oral bisphosphonate prevents aromatase-inhibitor-induced bone loss in postmenopausal women with osteopenia or osteoporosis who are at high risk of breast cancer. Full Text | PDF
CORRECTION
Statin therapy for skeletal dysplasia Jennifer SargentPublished online: 13 January 2015 p132 | doi:10.1038/nrendo.2015.2 Full Text | PDF
REVIEWS
Stromal cells and stem cells in clinical bone regeneration Warren L. Grayson, Bruce A. Bunnell, Elizabeth Martin, Trivia Frazier, Ben P. Hung & Jeffrey M. GimblePublished online: 06 January 2015 p140 | doi:10.1038/nrendo.2014.234Stromal cells and stem cells have been successfully used for bone-tissue-engineering applications in clinical trials; however, the routine use of these cells is far from being adopted into clinical practice. In this Review, Warren Grayson and colleagues discuss the scientific, technical, practical and regulatory obstacles that are preventing the widespread therapeutic use of stromal cells and stem cells to enhance skeletal repair. Abstract | Full Text | PDF
Long non-coding RNAs as regulators of the endocrine system Marko Knoll, Harvey F. Lodish & Lei SunPublished online: 06 January 2015 p151 | doi:10.1038/nrendo.2014.229Long non-coding RNAs (lncRNAs) have important roles in many physiological and pathological processes. The authors of this Review focus on the endocrine system and discuss the involvement of lncRNAs in the development and function of various endocrine organs, as well as the associations of lncRNAs with endocrine diseases such as diabetes mellitus and endocrine cancers. Abstract | Full Text | PDF
Insulin and IGF receptor signalling in neural-stem-cell homeostasis Amber N. Ziegler, Steven W. Levison & Teresa L. WoodPublished online: 02 December 2014 p161 | doi:10.1038/nrendo.2014.208Alterations in neural-stem-cell (NSC) homeostasis can contribute to the consequences of neurodegenerative diseases, healthy ageing and tissue repair after damage. This Review discusses emerging information on the function of insulin-like growth factors (IGFs) and IGF and/or insulin receptor signalling in the context of NSC regulation. The authors also propose a model for IGF-II in which the choroid plexus is a major component of the NSC niche. Abstract | Full Text | PDF
TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy Terry J. SmithPublished online: 06 January 2015 p171 | doi:10.1038/nrendo.2014.226Thyroid-associated ophthalmopathy (TAO) is an orbital manifestation of Graves disease. The pathogenesis of TAO is still not well understood and effective therapies for TAO are lacking. Here, Terry Smith reviews the processes that underlie autoimmunity and inflammation in the orbit of patients with TAO, with a focus on the role of infiltrating fibrocytes expressing the TSH receptor. Therapeutic implications are also discussed. Abstract | Full Text | PDF
PERSPECTIVES
OPINION Antibiotics in early life and obesity Laura M. Cox & Martin J. BlaserPublished online: 09 December 2014 p182 | doi:10.1038/nrendo.2014.210Colonization of an infant with their microbiota in early life is important for normal development of host metabolism. In this Perspectives article, Cox and Blaser posit that exposure to antibiotics that disrupt either vertical transmission or colonization and maturation of the microbiota in the infant can lead to adverse consequences such as obesity in adulthood. Abstract | Full Text | PDF
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