Nature Reviews Neuroscience contents March 2015 Volume 16 Number 3 pp 121-184

Advertisement
Need to head-fix awake, behaving rodents for high precision tests? Mobile HomeCage.  Combine in vivo two-photon imaging, patch clamp and multi-channel recordings, optogenetics or microdialysis with behavioral readouts.  Watch a video article. Ask for a quote and get a 10% discount until 31.3. 2015 (code MHCGO).
TABLE OF CONTENTS
March 2015 Volume 16 Number 3		Advertisement
Impact Factor31.376 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: The connectomics of brain disorders Alex Fornito, Andrew Zalesky & Michael Breakspear	Conquer Paralysis Now is offering 12 grants of at least $50,000 in 6 categories for research related to Spinal Cord Injury (SCI) treatments. The deadline to apply is April 1, 2015.  See the challenge for more information.
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature Genetics, Central South University, and Anhui Medical University present: Genome Variation in Precision Medicine 2015May 17-19, 2015 | Changsha, China Register Now!
RESEARCH HIGHLIGHTS Top Neural Circuits: A nucleus of fear p121 | doi:10.1038/nrn3932 Two studies show that the paraventricular nucleus of the thalamus is a component of fear-processing circuits. PDF Visual processing: An organizing wave? p122 | doi:10.1038/nrn3923 Saccadic eye movements elicit travelling waves of neural activity in area V4 in macaques that might have a role in the reorganization of spatiotemporal visual information. PDF Sensory systems: Noisy nociception p122 | doi:10.1038/nrn3926 A set of neurons in the cochlear organ of Corti is activated in response to noxious sound levels and thus mediates 'auditory nociception'. PDF Neurodegeneration: Selective vulnerability p123 | doi:10.1038/nrn3920 The subtype of motor neurons that is most likely to degenerate early in amyotrophic lateral sclerosis is prone to endoplasmic reticulum (ER) stress in mice, owing to low levels of SIL1, an ER-associated protein. PDF Pain: Reappraising pain p124 | doi:10.1038/nrn3919 A functional MRI study demonstrates that the nucleus accumbens and ventromedial prefrontal cortex mediate the effects of self-regulation on pain rating. PDF Synaptic plasticity: Cold-shocked synapses p124 | doi:10.1038/nrn3922 RNA-binding motif protein 3, a cold-shock protein, promotes synaptic regeneration and is neuroprotective in mouse models of Alzheimer disease and prion infection. PDF Autonomic nervous system: Go easy on the salt! p125 | doi:10.1038/nrn3925 A new study shows that high dietary salt causes hypertension through disruption of a feedback circuit from arterial baroreceptors to the hypothalamus,which leads to unregulated vasopressin release and peripheral vasoconstriction. PDF IN BRIEF Learning and memory:Emotional memory tagging | Cell biology of the neuron: Skin cells clear neuronal debris | Neuroimmunology: Immune cells drive resilience | Synaptic transmission: Transporter traffickingPDF Neuroscience JOBS of the week Post-doctoral Research Fellow Douglas Hospital Research Center - McGill Murray Endowed Chair Of Neuroscience Medical University of South Carolina Research Associate / Postdoc Fellow Baylor College of Medicine (BCM) Postdoctoral Fellow University of Tennessee Health Science Center Two Independent Junior Research Group Leader Positions – Vascular Biology - Neuroinflammation Institute for Stroke and Dementia Research (ISD) More Science jobs from Neuroscience EVENT British Association for Cognitive Neuroscience Annual Scientific Meeting, Essex 2015 10.09.15 University of Essex More science events from
PROGRESS
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders Scott A. Small & Gregory A. Petskop126 | doi:10.1038/nrn3896 Retromer is a protein assembly that has a crucial role in endosomal sorting and trafficking. In this Progress article, Small and Petsko discuss the role of retromer dysfunction in various neurological diseases, including Alzheimer disease and Parkinson disease. Abstract | Full Text | PDF
REVIEWS
Development, evolution and pathology of neocortical subplate neurons Anna Hoerder-Suabedissen & Zoltán Molnárp133 | doi:10.1038/nrn3915The subplate is a transient cortical zone that forms during mammalian brain development and has a crucial role in the formation of intracortical and extracortical circuits. Here, Hoerder-Suabedissen and Molnar review the changing architecture and cellular diversity of this zone in developing mouse and primate brains. Abstract | Full Text | PDF | Supplementary information
Exploring the origins of grey matter damage in multiple sclerosis Massimiliano Calabrese, Roberta Magliozzi, Olga Ciccarelli, Jeroen J. G. Geurts, Richard Reynolds & Roland Martinp147 | doi:10.1038/nrn3900Although often thought of as a disease of the white matter, multiple sclerosis is also characterized by prominent demyelination and degeneration in the grey matter. Calabrese and colleagues discuss current hypotheses regarding the inflammatory and non-inflammatory mechanisms of grey matter damage in multiple sclerosis and its relationship to white matter damage. Abstract | Full Text | PDF
The connectomics of brain disorders Alex Fornito, Andrew Zalesky & Michael Breakspearp159 | doi:10.1038/nrn3901Patholological perturbations of the brain can be described and modelled using network science. In this Review, Fornito, Zalesky and Breakspear discuss adaptive and maladaptive neural responses to such insults and consider how connectomics can be used to map, track and predict disease progression. Abstract | Full Text | PDF
PERSPECTIVES
OPINION Intrinsic plasticity: an emerging player in addiction Saïd Kourrich, Donna J. Calu & Antonello Boncip173 | doi:10.1038/nrn3877Exposure to drugs of abuse — for example, cocaine — leads to plastic changes in the activity of ion channels that control neuronal firing. In this Opinion article, Kourrich, Calu and Bonci discuss how accumulating evidence suggests that these changes may contribute to the shaping of addiction phenotype. Abstract | Full Text | PDF
Corrigendum: The warrior in the machine: neuroscience goes to war Irene Tracey & Rod Flowerp184 | doi:10.1038/nrn3914 Full Text | PDF
Advertisement
Nature Insight Frontiers in biology This year's Frontiers in Biology Insight covers the amygdala and how technology is helping us to understand its complex connectivity, innate lymphoid cells, nutrient-sensing mechanisms in mammals, a form of cell death called necroptosis, and the regulation and function of DNA methylation and its use as a cellular marker. Access the Insight online.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events