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Posted: 08 Feb 2015 12:27 PM PST
Combining experimental data from X-ray crystallography, NMR spectroscopy, cryoelectron microscopy and lipidomics, researchers have built a complete model of the outer envelope of an influenza A virion for the first time. The approach, known as a coarse-grained molecular dynamics simulation, has allowed them to generate trajectories at different temperatures and lipid compositions -- revealing various characteristics that may help scientists better understand how the virus survives in the wild or find new ways to combat it.
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Posted: 08 Feb 2015 12:27 PM PST
By employing derivatives of humanin, a naturally occurring peptide encoded in the genome of cellular mitochondria, researchers are working to interrupt necrosis, buying precious time for tissues whose cellular mechanisms have called it quits.
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Posted: 08 Feb 2015 12:27 PM PST
Good drugs are hard to design: they must not only effectively treat a medical condition, but they must also do so without having side effects that outweigh their benefits. Sometimes, toxic side effects aren't discovered until late in development, when substantial time and money have already been invested. Now, researchers have devised a new drug screen that capitalizes on the tendency of toxic compounds to alter the properties of the lipid bilayer that encases cells.
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Posted: 08 Feb 2015 12:27 PM PST
A large percentage of the world's population -- fully one third, by the World Health Organization's estimates -- is currently overweight or obese. This staggering statistics has made finding ways to address obesity a top priority for many scientists around the globe, and now a group of researchers has found promise in the potential of capsaicin -- the chief ingredient in chili peppers -- as a diet-based supplement.
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Posted: 08 Feb 2015 12:27 PM PST
Not unlike an urban restaurant, the success of a bacterial cell depends on three things: localization, localization and localization. But the complete set of controls by which bacteria control the movement of proteins and other essential biological materials globally within the confines of their membrane walls has been something of a mystery. Now, researchers have parsed out the localization mechanisms that E. coli use to sort through and organize their subcellular components.
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Posted: 06 Feb 2015 02:48 PM PST
A new study shows that emissions from e-cigarette aerosols and flavorings damage lung cells by creating harmful free radicals and inflammation in lung tissue, suggesting that e-cigarettes are likely a toxic replacement for tobacco products. The study also shows that some flavored e-juices -- particularly cinnamon -- create more stress and toxicity on lung tissue.
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