Nature Reviews Nephrology - Table of Contents alert Volume 11 Issue 3

TABLE OF CONTENTS
March 2015 Volume 11 Number 3
Impact Factor8.368 *	In this issue Editorial Research Highlights News and Views Reviews Perspectives Also this month  Web focus: Nephrology in the developing world
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EDITORIAL
The globalization of nephrology Susan J. AllisonPublished online: 24 February 2015 p125 | doi:10.1038/nrneph.2015.11 Full Text | PDF
RESEARCH HIGHLIGHTS Hypertension: Immediate reduction of blood pressure by iliac arteriovenous anastomosis Published online: 10 February 2015 p126 | doi:10.1038/nrneph.2015.12 PDF Clinical trials: Renal safety of TDF as pre-exposure prophylaxis for HIV-1 infection Published online: 20 January 2015 p127 | doi:10.1038/nrneph.2015.1 PDF Acute kidney injury: Protective role of gut microbial SCFAs Published online: 03 February 2015 p127 | doi:10.1038/nrneph.2015.10 PDF Biomarkers: How precise is NephroCheck®? Published online: 03 February 2015 p127 | doi:10.1038/nrneph.2015.7 PDF
NEWS AND VIEWS
Nephrology in the developing world: Chronic kidney disease in disadvantaged populations Guillermo Garcia-Garcia & Vivekanand Jha on behalf of the World Kidney Day Steering CommitteePublished online: 27 January 2015 p128 | doi:10.1038/nrneph.2015.4'Chronic kidney disease (CKD) in disadvantaged populations' is the focus of World Kidney Day 2015. In this article, we discuss the disproportionate burden of CKD in disadvantaged communities as well as approaches to ensure the provision of appropriate renal care across socioeconomic and ethnic groups. Full Text | PDF
Polycystic kidney disease: HALTing PKD progression—revival of blood pressure control Thomas BenzingPublished online: 16 December 2014 p129 | doi:10.1038/nrneph.2014.241New research suggests that rigorous blood pressure control is beneficial in early autosomal dominant polycystic kidney disease (ADPKD). Although a positive effect on the rate of decline of estimated glomerular filtration rate remains to be demonstrated, this study is likely to change current treatment strategies for young patients with ADPKD. Full Text | PDF
Clinical trials: Rituximab for maintenance of remission in AAV Anisha Tanna & Charles PuseyPublished online: 20 January 2015 p131 | doi:10.1038/nrneph.2014.254Maintenance therapy for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) should reduce rates of relapse with minimal toxicity. The MAINRITSAN trial—the first randomized controlled trial to compare the efficacies of rituximab and azathioprine in AAV remission maintenance—has demonstrated a superior outcome using rituximab. These data have important implications for the management of AAV. Full Text | PDF
Diabetes: Excess mortality in well-controlled T1DM without renal disease Janaka Karalliedde & Giancarlo VibertiPublished online: 20 January 2015 p132 | doi:10.1038/nrneph.2014.249The authors of a new study report that independent of renal disease, any level of glycaemia is associated with increased mortality risk in patients with type 1 diabetes mellitus. However, this view may be overly simplistic—a multifactorial approach is required to reduce excess mortality in this population. Full Text | PDF
Focus on: Nephrology in the developing world REVIEWS Birth weight, malnutrition and kidney-associated outcomes—a global concern Valerie A. Luyckx & Barry M. BrennerPublished online: 20 January 2015 p135 | doi:10.1038/nrneph.2014.251Fetal exposure to an adverse intrauterine environment is associated with an increased risk of numerous chronic diseases in later life. Here, Luyckx and Brenner highlight the emerging developmental risk factors for chronic kidney disease and hypertension, including high birth weight, maternal diabetes mellitus and rapid growth during childhood. The authors discuss the burden imposed on resource-poor countries by suboptimal nutritional intake, and address the benefits of nutritional interventions in reducing the global epidemic of these chronic diseases. Abstract | Full Text | PDF | Supplementary information HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment Avi Z. Rosenberg, Saraladevi Naicker, Cheryl A. Winkler & Jeffrey B. KoppPublished online: 17 February 2015 p150 | doi:10.1038/nrneph.2015.9HIV infection is associated with renal diseases including HIV-associated nephropathy, HIV-immune-complex kidney disease, thrombotic microangiopathy and disorders associated with nephrotoxic HIV therapies. Here, the authors review the epidemiology, histopathology, mechanisms, genetic susceptibility, diagnosis and treatment of HIV-associated nephropathies and highlight remaining questions for future research. Abstract | Full Text | PDF Sickle cell disease: renal manifestations and mechanisms Karl A. Nath & Robert P. HebbelPublished online: 10 February 2015 p161 | doi:10.1038/nrneph.2015.8The complex vascular pathobiology of sickle cell disease leads to renal manifestations that affect almost all physiological process in the kidney. Renal complications are diverse, ranging from altered haemodynamics and impaired urinary concentrating ability to glomerulopathies, chronic kidney disease, acute kidney injury and renal medullary carcinoma. In this Review, Karl A. Nath and Robert P. Hebbel provide an overview of sickle cell disease and consider the underlying pathogenetic mechanisms of the renal manifestations. Abstract | Full Text | PDF Hepatitis C and its impact on renal transplantation Jose M. Morales & Fabrizio FabriziPublished online: 03 February 2015 p172 | doi:10.1038/nrneph.2015.5Hepatitis C virus (HCV) infection imposes a substantial economic, clinical, and societal burden worldwide. In this Review, Morales and Fabrizi compare the treatment options that are available to patients with HCV infection, before and after renal transplantation. The development of novel therapeutic strategies and the clinical complications associated with HCV infection are discussed. The authors conclude with an assessment of the safe use of organs donated from individuals with active HCV infection. Abstract | Full Text | PDF | Supplementary information
Focus on: Nephrology in the developing world PERSPECTIVES SCIENCE AND SOCIETY Kidney care in Haiti—the role of partnerships Brian D. Remillard, Jean H. Buteau & Philip CléophatPublished online: 16 December 2014 p183 | doi:10.1038/nrneph.2014.239Implementation of programmes for dialysis, transplantation and renal-disease screening in developing countries is a complex and challenging task. Here, the authors provide the perspective of their efforts to implement renal care in Haiti. They focus on the importance of collaboration, education and partnership building, rather than on technological issues. Abstract | Full Text | PDF VIEWPOINT Access to medications and conducting clinical trials in LMICs Ikechi G. Okpechi, Charles R. Swanepoel & Francois VenterPublished online: 10 February 2015 p189 | doi:10.1038/nrneph.2015.6In many low-to-middle income countries (LMICs) access to essential medications is limited and the number of clinical trials conducted is small because of regulatory issues and a lack of infrastructure. In this article, Nature Reviews Nephrology asks three experts their opinions on how to improve drug access and increase the numbers of clinical trials conducted in LMICs. Abstract | Full Text | PDF
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