Nature Reviews Rheumatology - Table of Contents alert Volume 11 Issue 3

TABLE OF CONTENTS
March 2015 Volume 11 Number 3
Impact Factor10.252 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery William H. Robinson
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RESEARCH HIGHLIGHTS Top Inflammation: New classification criteria for autoinflammatory periodic fevers Published online: 17 February 2015 p125 | doi:10.1038/nrrheum.2015.15 PDF Clinical trials: Glucosamine-chondroitin combo improves knee OA pain Published online: 03 February 2015 p126 | doi:10.1038/nrrheum.2015.9 PDF Osteoarthritis: Activate autophagy to prevent cartilage degeneration? Published online: 10 February 2015 p127 | doi:10.1038/nrrheum.2015.12 PDF Rheumatoid arthritis:Another cog in the mechanism of methotrexate Published online: 27 January 2015 p127 | doi:10.1038/nrrheum.2015.3 PDF Bone: Anabolic Wnt/β-catenin signalling: osteocytes are key Published online: 10 February 2015 p128 | doi:10.1038/nrrheum.2015.11 PDF Epigenetics: Demethylation of IFN-regulated genes in SLE neutrophils Published online: 17 February 2015 p128 | doi:10.1038/nrrheum.2015.14 PDF IN BRIEF Connective tissue diseases:Lung transplantation in patients with SSc—acceptable risk? | Risk factors:Cardiovascular risk in patients with psoriatic arthritis | Osteoarthritis:Structural damage associated with knee pain in OAPDF Rheumatology JOBS of the week Scientists Emory University More Science jobs from
NEWS AND VIEWS
Autoimmunity: Basophils in autoimmune and inflammatory diseases Meenu Sharma & Jagadeesh BayryPublished online: 25 November 2014 p129 | doi:10.1038/nrrheum.2014.199Basophils are classically known for their pathogenic role in asthma and allergic skin conditions. However, reports suggest that basophil activation mediated by autoreactive IgE, thymic stromal lymphopoietin or Toll-like receptors has an important role in the pathogenesis of lupus nephritis, eosinophilic oesophagitis and IgG4-related diseases, respectively. Full Text | PDF
Genetics: Mapping autoimmune disease epigenetics: what's on the horizon? Chrysothemis C. Brown & Lucy R. WedderburnPublished online: 16 December 2014 p131 | doi:10.1038/nrrheum.2014.210Can a patient's genotype provide insight into the mechanistic basis of autoimmune disease? A study integrating epigenetic data with finely mapped disease-associated variants sheds light on how noncoding variants might alter gene expression within specific immune cells, and hints at new possibilities for individualizing treatment of autoimmune rheumatic disorders. Full Text | PDF
Osteoarthritis: What is the evidence for valgus bracing effects in knee OA? Kim L. Bennell & Rana S. HinmanPublished online: 27 January 2015 p132 | doi:10.1038/nrrheum.2015.2Recommendations for the use of valgus bracing for knee osteoarthritis are inconsistent. Two new complementary systematic reviews and meta-analyses—concentrating on biomechanical factors and clinical effects, respectively—raise practical issues and suggest future research directions. Full Text | PDF
REVIEWS
Vaccination of patients with autoimmune inflammatory rheumatic diseases Johanna Westra, Christien Rondaan, Sander van Assen & Marc BijlPublished online: 09 December 2014 p135 | doi:10.1038/nrrheum.2014.206Patients with autoimmune inflammatory rheumatic diseases have an impaired immune system that can be exacerbated by medication, making them susceptible to infectious diseases. This article reviews this problem and the potential compounding issue that vaccinating these patients against common infectious diseases is not always safe and effective. Abstract | Full Text | PDF
A vascular mechanistic approach to understanding Raynaud phenomenon Nicholas A. FlavahanPublished online: 23 December 2014 p146 | doi:10.1038/nrrheum.2014.195This article places Raynaud phenomenon in the context of a mechanistic understanding of cutaneous vasoconstrictive and thermoregulatory processes, describing how these processes might regulate the pathogenesis of Raynaud phenomenon and ultimately inform new approaches to its treatment. Abstract | Full Text | PDF
TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs Rodolfo Gómez, Amanda Villalvilla, Raquel Largo, Oreste Gualillo & Gabriel Herrero-BeaumontPublished online: 16 December 2014 p159 | doi:10.1038/nrrheum.2014.209Disease-modifying osteoarthritis (OA) drugs (DMOADs) are needed as current OA therapies only relieve pain and do not alter the course of disease. In this article, Toll-like receptor 4 (TLR4) signalling, which is involved at various stages of pathogenesis, is reviewed, as is the potential for candidate TLR4-specific DMOADs. Abstract | Full Text | PDF
Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery William H. RobinsonPublished online: 23 December 2014 p171 | doi:10.1038/nrrheum.2014.220Next-generation sequencing is at the forefront of the identification and characterization of clonal families of antibodies that are involved in immune responses to infection, cancer and autoimmune disease. In this article, cutting-edge antibody repertoire sequencing technologies are described as a means of paving the way forward for research and discovery in rheumatology. Abstract | Full Text | PDF
PERSPECTIVES
SCIENCE AND SOCIETY Article series: APLAR Perspectives Rheumatology in India—quo vadis? Rohini HandaPublished online: 04 November 2014 p183 | doi:10.1038/nrrheum.2014.182The treatment of rheumatic diseases in India is beset with several problems, such as a high patient load and grossly inadequate number of trained rheumatology specialists. In this Perspectives article, Handa explores the most pressing challenges and suggests helpful approaches to overcome the limitations in rheumatology care in India. Abstract | Full Text | PDF
OPINION Alternative pathways of osteoclastogenesis in inflammatory arthritis Iannis E. Adamopoulos & Elizabeth D. MellinsPublished online: 25 November 2014 p189 | doi:10.1038/nrrheum.2014.198In this Perspectives article, the authors argue that the cells of the inflammatory infiltrate and the cytokine milieu provide multiple routes to bone destruction in inflammatory arthritis. They first summarize the physiological pathway of osteoclastogenesis, then present emerging evidence of the contribution of various cytokines and cell types to alternative pathways of osteoclast differentiation and activation. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.