Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 12 Issue 3

TABLE OF CONTENTS
March 2015 Volume 12 Number 3
Impact Factor10.807 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Dietary management of IBD—insights and advice Emma P. Halmos & Peter R. Gibson
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RESEARCH HIGHLIGHTS Colorectal cancer:Combining drug therapies to improve treatment efficacy in metastatic colorectal cancer Published online: 17 February 2015 p121 | doi:10.1038/nrgastro.2015.29 PDF Biliary tract: A new mouse model that closely resembles human cholangiocarcinoma Published online: 27 January 2015 p122 | doi:10.1038/nrgastro.2015.10 PDF IBD: Gut microbiota in IBD goes viral Published online: 10 February 2015 p122 | doi:10.1038/nrgastro.2015.26 PDF NAFLD: Leaky guts: intestinal permeability and NASH Published online: 03 February 2015 p123 | doi:10.1038/nrgastro.2015.15 PDF Hepatocellular carcinoma:Working it out—exercise reduces HCC but not steatosis in mice Published online: 10 February 2015 p124 | doi:10.1038/nrgastro.2015.27 PDF Gastric cancer: Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer Published online: 27 January 2015 p124 | doi:10.1038/nrgastro.2015.9 PDF IN BRIEF Liver: Regulation of the ductular reaction by pleiotrophin | Hepatitis:High HCV cure-rate on a 6 week course of DAAs |Helicobacter pylori :Optimizing treatment ofHelicobacter pylori infection| Coeliac disease: Age at gluten introduction is not an independent risk factor for coeliac diseasePDF Gastroenterology & Hepatology  JOBS of the week Gastroenterology - Clinical Director Loma Linda University Health General Gastroenterology / Advanced Endoscopy - Assistant Professor Texas Tech University Health Sciences Center Faculty Position in the Division of Gastroenterology & Hepatology Washington Hospital Center More Science jobs from Gastroenterology & Hepatology  EVENT International Workshop on Gastroenterology 21.07.15 Istanbul, Turkey More science events from
NEWS AND VIEWS
Developmental biology: Regional identity of gut stem cells—one gene to rule them all James M. WellsPublished online: 03 February 2015 p125 | doi:10.1038/nrgastro.2015.22The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2. Full Text | PDF
NAFLD: Accurate quantification of hepatic fat—is it important? Leon A. AdamsPublished online: 10 February 2015 p126 | doi:10.1038/nrgastro.2015.23New ultrasonography and MRI techniques offer the promise of accessible and accurate quantification of hepatic steatosis. Application of these techniques to help define the natural history and severity of NAFLD is required before we can determine their clinical utility. Full Text | PDF
Gut microbiota: Microbiota organization—a key to understanding CRC development Georgina L. Hold & Wendy S. GarrettPublished online: 17 February 2015 p128 | doi:10.1038/nrgastro.2015.25The gut microbiota has an important role in colorectal cancer (CRC). Dejea and colleagues have demonstrated that particular bacterial biofilms are associated with proximal CRC, correlating with changes in tissue biology associated with oncogenesis. These findings provide a fresh perspective on the microbiota in cancer: microbial organization might provide critical insight into understanding CRC development. Full Text | PDF
Viral hepatitis: HBV cure—can we pin our hopes on immunotherapy? Hung-Chih Yang & Jia-Horng KaoPublished online: 27 January 2015 p129 | doi:10.1038/nrgastro.2015.8Therapeutic vaccines are considered to be able to reverse the dysfunctional immune state of chronic hepatitis B and thus hold the promise for HBV cure. Martin et al. developed a novel adenovirus-based therapeutic vaccine TG1050 and demonstrated its induction of long-lasting antiviral CD8+ T-cell immunity in mouse models of HBV persistence. Full Text | PDF
Gastrointestinal bleeding: Gastrointestinal bleeding risk is increased by novel anticoagulants Don C. RockeyPublished online: 20 January 2015 p131 | doi:10.1038/nrgastro.2015.7A report has demonstrated that in patients with atrial fibrillation the novel oral anticoagulant, dabigatran, increases the risk of gastrointestinal bleeding by nearly twofold compared with warfarin. Here, the risk of gastrointestinal bleeding associated with anticoagulants and antiplatelet agents is placed into clinical context and key management principles are emphasized. Full Text | PDF
REVIEWS
Dietary management of IBD—insights and advice Emma P. Halmos & Peter R. GibsonPublished online: 03 February 2015 p133 | doi:10.1038/nrgastro.2015.11Diet is one of the main behavioural factors manipulated by patients with IBD, but dietary advice has only a minor part in current treatment guidelines. Here, Halmos and Gibson describe a step-wise approach to the dietary management of IBD, detailing dietary and nutritional assessments and how diet can potentially influence disease activity, symptoms and disease prevention. Abstract | Full Text | PDF | Supplementary information
Novel therapeutic targets in primary biliary cirrhosis Jessica K. Dyson, Gideon M. Hirschfield, David H. Adams, Ulrich Beuers, Derek A. Mann, Keith D. Lindor & David E. J. JonesPublished online: 03 February 2015 p147 | doi:10.1038/nrgastro.2015.12Primary biliary cirrhosis (PBC) leads to progressive cholestasis, biliary fibrosis and cirrhosis and characteristic symptoms with a marked effect on quality of life. Evolution in our understanding of disease mechanisms in PBC is rapidly leading to the advent of new and re-purposed therapeutic agents targeting key processes. This Review provides a current perspective on potential approaches to PBC treatment, and highlights the challenges faced in evaluating and implementing those treatments. Abstract | Full Text | PDF | Supplementary information
Childhood functional abdominal pain: mechanisms and management Judith Korterink, Niranga Manjuri Devanarayana, Shaman Rajindrajith, Arine Vlieger & Marc A. BenningaPublished online: 10 February 2015 p159 | doi:10.1038/nrgastro.2015.21Chronic abdominal pain is common in children, but poorly understood. This Review summarizes the mechanisms and management of childhood functional abdominal pain in a bid to improve understanding and quality of care. The article provides up-to-date information on the epidemiology, pathophysiology, diagnosis and therapeutic management of this common childhood condition. Abstract | Full Text | PDF
Software for enhanced video capsule endoscopy: challenges for essential progress Dimitris K. Iakovidis & Anastasios KoulaouzidisPublished online: 17 February 2015 p172 | doi:10.1038/nrgastro.2015.13Video capsule endoscopy has revolutionized the diagnostic work-up in the field of small bowel diseases and could be applied to screening the entire gastrointestinal tract. This Review focuses on computational methods that can be implemented in software to enhance video capsule endoscopy procedures in terms of time efficiency and diagnostic performance. Abstract | Full Text | PDF
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