Scientific Reports Health Sciences Table of Contents e-alert: 10 March 2015

10 March 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         nature.com webcasts Nature Publishing Group presents a custom webcast on: Using cellular reprogramming and live cell identification to advance cardiac disease modelling   Wednesday 18 March, 8AM PDT, 11AM EDT, 3PM GMT, 4PM CET Register for the webcast and live Q & A session    Sponsored by: EMD Millipore           Health Sciences               In vivo Quantification of the Structural Changes of Collagens in a Melanoma Microenvironment with Second and Third Harmonic Generation Microscopy ▶     Pei-Chun Wu, Tsung-Yuan Hsieh, Zen-Uong Tsai et al.     Using in vivo second harmonic generation (SHG) and third harmonic generation (THG) microscopies, we tracked the course of collagen remodeling over time in the same melanoma …             It takes acid, rather than ice, to freeze glucose ▶     S. A. A. van den Berg, M. H. M. Thelen, L. P. W. Salden et al.     Plasma glucose levels provide the cornerstone of diabetes evaluation. Unfortunately, glucose levels drop in vitro due to glycolysis. Guidelines provide suitable conditions which …             Using Mobile Phone Data to Predict the Spatial Spread of Cholera ▶     Linus Bengtsson, Jean Gaudart, Xin Lu et al.     Effective response to infectious disease epidemics requires focused control measures in areas predicted to be at high risk of new outbreaks. We aimed to test whether mobile …             Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension ▶     Agata Bielecka-Dabrowa, Marta Michalska-Kasiczak, Anna Gluba et al.     The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. …             Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits ▶     Yi-Xin He, Jin Liu, Baosheng Guo et al.     To examine the therapeutic effect of Src inhibitor on the VEGF mediating vascular hyperpermeability and bone destruction within steroid-associated osteonecrotic lesions in …             Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression ▶     Jing Zhao, Yang-Hee Jung, Choon-Gon Jang et al.     Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: …             Testosterone regulates the autophagic clearance of androgen binding protein in rat Sertoli cells ▶     Yi Ma, Hao-Zheng Yang, Long-Mei Xu et al.     Dysregulation of androgen-binding protein (ABP) is associated with a number of endocrine and andrology diseases. However, the ABP metabolism in Sertoli cells is largely unknown. …             A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus ▶     Qingpeng Ren, Chan Li, Pengfei Yuan et al.     The hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and hepatocellular carcinomas and infects approximately 170 million people …             Paramagnetic Nanoparticles as a Platform for FRET-Based Sarcosine Picomolar Detection ▶     Zbynek Heger, Natalia Cernei, Sona Krizkova et al.     Herein, we describe an ultrasensitive specific biosensing system for detection of sarcosine as a potential biomarker of prostate carcinoma based on Förster resonance energy …             CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity ▶     Hasiyeti Maimaitiyiming, Heather Norman, Qi Zhou et al.     CD47 is a transmembrane protein with several functions including self-recognition, immune cell communication, and cell signaling. Although it has been extensively studied in …             Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity ▶     Yanhong Li, Xiaochun Feng, Lan Huang et al.     Henoch-Schönlein purpura (HSP) is a common systemic vasculitis in children. Animal models of HSP are needed to better understand the mechanism of HSP. Here, we investigated …             (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma ▶     Yuki Shibayama, Takayuki Fujimori, Genevieve Nguyen et al.     Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting …             Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets▶     Hadi Shafiee, Waseem Asghar, Fatih Inci et al.     The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring …             A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder ▶     Liang-Jen Wang, Sheng-Yu Lee, Shiou-Lan Chen et al.     Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in …             Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint ▶     Yingjie Li, Loaye Abdelaziz El.Mozen, Hengxing Cai et al.     Synovial chondromatosis (SC) of temporomandibular joint is rare proliferative disorder featured by the formation of cartilaginous nodules in synovium and joint space. …             Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles ▶     Hanwook Park, Eunseop Yeom, Seung-Jun Seo et al.     Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV …             Outlier-resilient complexity analysis of heartbeat dynamics ▶     Men-Tzung Lo, Yi-Chung Chang, Chen Lin et al.     Complexity in physiological outputs is believed to be a hallmark of healthy physiological control. How to accurately quantify the degree of complexity in physiological signals …             Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis ▶     Chad McKee, Barbara Sigala, Junpei Soeda et al.     Amphiregulin (AR) involvement in liver fibrogenesis and hepatic stellate cells (HSC) regulation is under study. Non-alcoholic fatty liver disease (NAFLD) and its more severe form …             Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas ▶     Toru Furukawa, Hitomi Sakamoto, Shoko Takeuchi et al.     Acinar cell carcinoma of the pancreas is a rare tumor with a poor prognosis. Compared to pancreatic ductal adenocarcinoma, its molecular features are poorly known. We studied a …             3D Pharmacophoric Similarity improves Multi Adverse Drug Event Identification in Pharmacovigilance ▶     Santiago Vilar, Nicholas P. Tatonetti, George Hripcsak     Adverse drugs events (ADEs) detection constitutes a considerable concern in patient safety and public health care. For this reason, it is important to develop methods that …             Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host ▶     Munehiro Okamoto, Takayuki Miyazawa, Shigeru Morikawa et al.     We discovered a lethal hemorrhagic syndrome arising from severe thrombocytopenia in Japanese macaques kept at the Primate Research Institute, Kyoto University. Extensive …             Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes ▶     Bahram Sanjabi, Monireh Dashty, Behiye Özcan et al.     Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes …             Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis ▶     Huanzi Dai, Huhai Zhang, Yani He     The diagnostic performance of M-type phospholipase A2 receptor (PLA2R) autoantibodies and PLA2R glomerular staining in discriminating between idiopathic membranous nephropathy …             Prognostic Impact of HOTAIR Expression is Restricted to ER-Negative Breast Cancers ▶     Yesim Gökmen-Polar, I. Tudor Vladislav, Yaseswini Neelamraju et al.     Expression of HOX transcript antisense intergenic RNA (HOTAIR), a large intergenic noncoding RNA (lincRNA), has been described as a metastases-associated lincRNA in various …             The Plasmodium vivax in China: decreased in local cases but increased imported cases from Southeast Asia and Africa ▶     Jun Feng, Huihui Xiao, Li Zhang et al.     Currently the local P. vivax was sharply decreased while the imported vivax malaria increased in China. Despite Southeast Asia was still the main import source of vivax malaria, …             Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies ▶     Beibei Zhu, Yu Sun, Lu Qi et al.     Previous epidemiological studies on the relation between dietary legume consumption and risk of colorectal cancer (CRC) remain controversial. We conducted a meta-analysis based …             Uterine artery impedance during the first eight postpartum weeks ▶     L. Guedes-Martins, A. R. Gaio, J. Saraiva et al.     The aim of this study was to construct reference ranges for the uterine artery (UtA) mean pulsatility (PI) and resistance (RI) indices from 1–8 weeks postpartum. A prospective, …             Excess of Rare Variants in Genes that are Key Epigenetic Regulators of Spermatogenesis in the Patients with Non-Obstructive Azoospermia ▶     Zesong Li, Yi Huang, Honggang Li et al.     Non-obstructive azoospermia (NOA), a severe form of male infertility, is often suspected to be linked to currently undefined genetic abnormalities. To explore the genetic basis …             The relationship between response inhibition and posttraumatic stress symptom clusters in adolescent earthquake survivors: An event-related potential study ▶     Jianhui Wu, Yiran Yuan, Chengqi Cao et al.     Posttraumatic stress disorder (PTSD) patients experience impaired response inhibition. Little is known about the relationship between response inhibition abnormalities and …             Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury ▶     Gregor Lorbek, Martina Perše, Jera Jeruc et al.     We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific …             Double-scattering/reflection in a Single Nanoparticle for Intensified Ultrasound Imaging ▶     Kun Zhang, Hangrong Chen, Xiasheng Guo et al.     Ultrasound contrast agents (UCAs) designed by the conventional composition-based strategy, often suffer from relatively low ultrasound utilization efficiency. In this report, a …             Pulmonary Tuberculosis Caused by Mycobacterium bovis in China ▶     Guanglu Jiang, Guirong Wang, Suting Chen et al.     The epidemiology of Mycobacterium bovis infection in humans in China is unknown. In this study, pulmonary tuberculosis caused by M. bovis in China was studied. A total of 4069 …             The anti-fibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2 ▶     Li-Hua Dong, Yi-Yao Jiang, Yong-Jun Liu et al.     Radiation-induced pulmonary fibrosis is a common disease and has a poor prognosis owing to the progressive breakdown of gas exchange regions in the lung. Recently, a novel …             Quantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry ▶     Susu Pan, Yong Tian, Ming Li et al.     Exhaled nitric oxide (eNO) is a useful biomarker of various physiological conditions, including asthma and other pulmonary diseases. Herein a fast and sensitive analytical method …             Modeling Post-death Transmission of Ebola: Challenges for Inference and Opportunities for Control ▶     Joshua S. Weitz, Jonathan Dushoff     Multiple epidemiological models have been proposed to predict the spread of Ebola in West Africa. These models include consideration of counter-measures meant to slow and, …             Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging ▶     Jin Tae Kwak, André Kajdacsy-Balla, Virgilia Macias et al.     Precise Outcome prediction is crucial to providing optimal cancer care across the spectrum of solid cancers. Clinically-useful tools to predict risk of adverse events …             Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry ▶     Frederik Weiß, Anke Schnabel, Hannes Planatscher et al.     Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies …             Microreactor Array Device ▶     Peter Wiktor, Al Brunner, Peter Kahn et al.     We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible …             Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies ▶     Pramod Kumar, Abhigyan Satyam, Xingliang Fan et al.     Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the …             Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice ▶     Yalda Khosravi, Shih Wee Seow, Arlaine Anne Amoyo et al.     Helicobacter pylori, is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade …             Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex ▶     Wonhye Lee, Hyungmin Kim, Yujin Jung et al.     Focused ultrasound (FUS) has recently been investigated as a new mode of non-invasive brain stimulation, which offers exquisite spatial resolution and depth control. We report on …             Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways ▶     Wen Gu, Lin Song, Xiao-Ming Li et al.     Bone marrow-derived mesenchymal stem cells (MSCs) have been identified as one possible strategy for the treatment of chronic obstructive pulmonary disease (COPD). Our previous …             Evaluation of 68Ga-Labeled MG7 Antibody: A Targeted Probe for PET/CT Imaging of Gastric Cancer ▶     Bing Xu, Xiaowei Li, Jipeng Yin et al.     MG7-Ag, a specific gastric cancer-associated antigen, can be used to non-invasively monitor gastric cancer by molecular imaging with positron emission tomography/computed …             Diagnostic and Prognostic Significances of MUC5B and TTF-1 Expressions in Resected Non-Small Cell Lung Cancer ▶     Ryo Nagashio, Junpei Ueda, Shinichiro Ryuge et al.     To investigate the relationships between the expression of MUC5B and clinicopathological parameters, the expression of MUC5B was immunohistochemically studied. MUC5B expression …             Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo ▶     Xingxing He, Fang Liu, Jingjun Yan et al.     Reactivation of wild-type p53 (wt-p53) function is an attractive therapeutic approach to p53-defective cancers. An ideal p53-based gene therapy should restore wt-p53 production …             MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro ▶     Ruizhi Feng, Qing Sang, Yan Zhu et al.     Previous work from our laboratory demonstrated the existence of miRNAs in human follicular fluid. In the current study, we have sought to identify miRNAs that might affect …             Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle ▶     Gilles Gouspillou, Celena Scheede-Bergdahl, Sally Spendiff et al.     Anticancer treatments for childhood acute lymphoblastic leukaemia (ALL) are highly effective but are now implicated in causing impaired muscle function in long-term survivors. …             C2 rs547154 polymorphism and polypoidal choroidal vasculopathy susceptibility: a meta-analysis▶     Xue Chen, Xiaoli Kang, Kanxing Zhao et al.     Previous studies have indicated the association between C2 rs547154 polymorphism and polypoidal choroidal vasculopathy (PCV) risk, while the results are controversial and …             Inspections of radiocesium concentration levels in rice from Fukushima Prefecture after the Fukushima Dai-ichi Nuclear Power Plant accident ▶     Naoto Nihei, Keitaro Tanoi, Tomoko M. Nakanishi     We summarize the inspections of radiocesium concentration levels in rice produced in Fukushima Prefecture, Japan, for 3 years from the nuclear accident in 2011. In 2011, three …             Pre-activation of mesenchymal stem cells with TNF-α, IL-1β and nitric oxide enhances its paracrine effects on radiation-induced intestinal injury ▶     Hao Chen, Xiao-Hui Min, Qi-Yi Wang et al.     Conditioned medium from mesenchymal stem cells (MSC-CM) may represent a promising alternative to MSCs transplantation, however, the low concentrations of growth factors in …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Postdoctoral Scientist     University of Southern California            Research Associate     University College London (UCL)            MSc / PhD Studentship     Dundalk Institute of Technology (DkIT)            Postdoctoral Fellow     Blood Center of Wisconisn            Postdoctoral Research Assistant     University of Oxford            Postdoctoral Research Fellow     University of Leeds            Research Fellow     University of Sussex            Postdoctoral Position     German Cancer Research Center (DKFZ)            Impacts Research Manager     Marine Stewardship Council (MSC)            Postgraduate fellow     Yale University School of Medicine          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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