| BioProcess Online Newsletter | February 18, 2015 |
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 | | CHT™ Ceramic Hydroxyapatite. Discover How Direct The Path To Purity Can Be.
CHT offers unique selectivity that effectively removes aggregates and the full range of process- and product-related impurities. While other approaches may require extensive development and tight process control, CHT methods are easy to develop and chromatographically robust, thus predictably delivering unmatched clearance performance in any situation. Learn more. |
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| A Powerful Method To Develop Highly Concentrated Protein Formulations |
By Michelle Amaral, Ph.D., Science Writer, Soluble Therapeutics
Proteins perform an array of functions in living organisms, from structural scaffolds and signaling molecules to catalysts and cell-surface receptors. Structural perturbations and aberrant protein production are associated with many disease states, making these macromolecules potential candidates for pharmaceuticals. |
| Optimization Of Monoclonal Antibody Production Employing Noninvasive Sensor Technology |
By Handrick, R., Kozakiewicz, F., Doederlein, T., Schad, M., Riechers, D., Otte, K., and Hannemann, J., Sartorius Stedim Biotech
Large-scale high-density fermentation and high-yield production of monoclonal antibodies are major aims of process development in the biopharmaceutical industry. |
| Dangerous Goods Classification Confusion: UN 3373 Biological Substance, Category B |
By Michael Gotz, QuickSTAT
In the previous blog post, Infectious Biologicals Category A and B — Classification Guidelines, I provided definitions of Infectious Biologicals Category A and B and some basic guidelines on how to classify your shipments. These definitions are clear and helpful when you know that your shipment contains pathogens. In that case, it is either on the list for Category A, or if it is not, then it is classified as Category B. |
| The Effect Of Conductivity On Dynamic Binding Capacity On CEX Resins |
By Mira A. Linhart, Michael W.T. Huang, Michael Clark, Vijay Sharma, Stephen Lu, and Natraj Ramasubramanyan, Abbot Bioresearch Center
In an effort to improve the antibody manufacturing platform, newer cation exchange resins were evaluated. |
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| An Affordable Way To Ship Temperature-Sensitive Cargo |
| Today, the demand for transporting medical and pharmaceutical products is exploding. So too are the challenges associated with moving time- and temperature-sensitive cargo in a manner that keeps the cold chain intact, and ensures documented quality of delivery. |
| Induction And Inhibition Studies Of Hypoxia And Oxidative Stress In Immortalized Keratinocytes |
| Hypoxic skin injuries are an important pathological process in many diseases. It has been shown that oxidative stress, the overproduction of reactive oxygen species (ROS), is intimately associated with hypoxic injury of skin. |
| Handheld Particle Counter With High-Resolution Display |
| At only 1.5 pounds, the MET ONE HHPC+ slim design allows single-handed operation. Perfect for effortless troubleshooting of particle problems such as filter leaks in mini environments and workstations. |
| Fermentation Valve Monitor: BioPAT Spectro |
| Monitoring the process values during biotechnological fermentations is of high importance for maintaining a high efficiency and quality of a bioprocess. For some variables, such as pH-value or the concentration of dissolved oxygen, commercial sensor systems for real-time monitoring are available. |
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